Gait Analysis in Rodents
Abstract
Gait abnormality might occur due to problems in the nervous system and the musculoskeletal system. The problems in the nervous system, that impairs the patient’s mobility, includes neurodegenerative disorder in the brain and lesions in the spinal cord.
In the preclinical investigation of the disease development and progression, animal models are widely used. For evaluating the motoric symptoms, sensitive assays with a quantifiable output are essential. One of the behavioral tests, which is commonly used, is an automated runway locomotion analysis for rodents, named CatWalk XT (Noldus Information Technology, Wageningen, Netherlands).
The research aims to develop clinically relevant feature descriptors and gait analysis in rodent by implementing and adapting machine learning, signal processing, image processing and data analysis approaches.
The analysis of alpha-synuclein mice gait was studied in sub-project. This alpha-synuclein mouse model is relevant to a neurodegenerative disorder, namely Parkinson’s disease. Based on signal processing approaches, new parameters related to mice locomotion sway has been developed in the study.
Collaborators
- Georgia Minakaki, Frederik Bode, Stefanie Menges, Holger Meixner, PD Dr. med. Jochen Klucken and Prof. Dr. Jürgen Winkler
- Prof. Dr. med. Rolf Schröder and Dr. Frederik Chevessier
- Dr. Fabio Canneva and Prof. Dr. Stephan von Hörsten
- Prof Dr. Olaf H. Riess and Nicolas Casadei
- Ivanna K. Timotius, Dr. Cristian Pasluosta and Prof. Dr. Björn Eskofier
Related publication
- Timotius I., Canneva F., Minakaki G., Moceri S., Casadei N., Riess O., Winkler J., von Hörsten S., Eskofier B., Klucken J.:
Systematic Data Analysis and Data Mining in Gait Analysis by Heat Mapping
11th International Conference on Methods and Techniques in Behavioral Research (Manchester, 5. June 2018 - 8. June 2018)
In: Robyn Grant, Tom Allen, Andrew Spink (ed.): Measuring Behavior 2018, UK: 2018
Open Access: https://www.measuringbehavior.org/mb2018/Publications
URL: https://www.measuringbehavior.org/mb2018/Publications
BibTeX: Download
- Timotius I., Canneva F., Minakaki G., Pasluosta CF., Moceri S., Casadei N., Riess O., Winkler J., Klucken J., von Hörsten S., Eskofier B.:
Dynamic footprints of α-synucleinopathic mice recorded by CatWalk gait analysis
In: Data in Brief 17 (2018), p. 189-193
ISSN: 2352-3409
DOI: 10.1016/j.dib.2017.12.067
URL: https://www.sciencedirect.com/science/article/pii/S2352340918300015
BibTeX: Download
- Timotius I., Canneva F., Minakaki G., Pasluosta CF., Moceri S., Casadei N., Riess O., Winkler J., Klucken J., von Hörsten S., Eskofier B.:
Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter
In: Journal of Neuroscience Methods 296 (2018), p. 1-11
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2017.12.004
URL: http://www.sciencedirect.com/science/article/pii/S0165027017304211
BibTeX: Download
- Minakaki G., Canneva F., Chevessier F., Bode F., Menges S., Timotius I., Kalinichenko L., Meixner H., Müller CP., Eskofier B., Casadei N., Riess O., Schröder R., Winkler J., Xiang W., von Hörsten S., Klucken J.:
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy
In: Behavioural Brain Research 363 (2019), p. 199-215
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2018.11.035
URL: https://www.sciencedirect.com/science/article/pii/S016643281830754X
BibTeX: Download
- Timotius I., Canneva F., Minakaki G., Moceri S., Plank AC., Casadei N., Riess O., Winkler J., Klucken J., Eskofier B., von Hörsten S.:
Systematic data analysis and data mining in CatWalk gait analysis by heat mapping exemplified in rodent models for neurodegenerative diseases
In: Journal of Neuroscience Methods 326 (2019), Article No.: 108367
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2019.108367
URL: https://www.sciencedirect.com/science/article/pii/S0165027019302249
BibTeX: Download
Longitudinal gait data from alpha-synuclein rat model (Parkinson’s-disease-relevant) and BACHD mouse model (Huntington-disease-relevant) are studied in this sub-project.
Collaborators
- PD Dr. med. Jochen Klucken and Prof. Dr. Jürgen Winkler
- Sandra Moceri, Johanna Habermeyer, Anne-Christine Plank, Dr. Fabio Canneva and Prof. Dr. Stephan von Hörsten
- Ivanna K. Timotius and Prof. Dr. Björn Eskofier
Related publication
- Timotius I., Moceri S., Plank AC., Habermeyer J., Canneva F., Winkler J., Klucken J., Casadei N., Riess O., Eskofier B., von Hörsten S.:
Silhouette-Length-Scaled Gait Parameters for Motor Functional Analysis in Mice and Rats
In: eNeuro 6 (2019), Article No.: ENEURO.0100-19.2019
ISSN: 2373-2822
DOI: 10.1523/ENEURO.0100-19.2019
URL: https://www.eneuro.org/content/6/6/ENEURO.0100-19.2019
BibTeX: Download
- Timotius I., Moceri S., Plank AC., Habermeyer J., Canneva F., Casadei N., Riess O., Winkler J., Klucken J., Eskofier B., von Hörsten S.:
Rodent’s Stride Length Depends on Body Size: Implications for CatWalk Assay
11th International Conference on Methods and Techniques in Behavioral Research (Measuring Behavior 2018) (Manchester, 5. June 2018 - 8. June 2018)
In: Robyn Grant, Tom Allen, Andrew Spink, Matthew Sullivan (ed.): Measuring Behavior 2018, UK: 2018
Open Access: https://www.measuringbehavior.org/mb2018/Publications
URL: https://www.measuringbehavior.org/mb2018/Publications
BibTeX: Download
- Moceri S., Canneva F., Habermeyer J., Dobner J., Schulze-Krebs A., Puchades M., Bjaalie JG., Kohl Z., Winkler J., Timotius I., Eskofier B., Schilling S., Demuth HU., Hartlage-Rübsamen M., Rossner S., Casadei N., Riess O., von Hörsten S.:
Association of early phenotypic behavioral alterations in human alpha-synuclein overexpressing transgenic rats with alpha-synuclein/huntingtin/amyloid-beta protein cross-seeding
Advances in Alzheimer's and Parkinson's Therapies an AAT-AD/PD Focus Meeting (Torino, 15. March 2018 - 18. March 2018)
In: Advances in Alzheimer's and Parkinson's Therapies an AAT-AD/PD Focus Meeting 2018
BibTeX: Download
The recovery development in the gait of Thoracic 8 spinal cord injuries rats is studied in this sub-project.
Collaborators
- Dr. rer. nat. Radhika Puttagunta and Dr. rer. nat. Beatrice Sandner – Heidelberg University Hospital, Germany
- Dr. rer. nat. Veronica Estrada and Hans W. Müller – University of Düsseldorf, Germany
- Daniel Garcia-Ovejero and Florencia Labombarda – Hospital Nacional de Paraplejicos (SESCAM), Spain
- Lara Bieler and Sebastien Couillard-Despres – Paracelsus Medical University, Austria
- Jochen Klucken and Jürgen Winkler – University Hospital Erlangen, Germany
- Ivanna K. Timotius and Prof. Dr. Björn Eskofier